Chapters 1 through 7 explain anatomical orientation, tissues, bones, the axial and appendicular skeletons, joints, and skeletal muscles and fascia. Subsequent chapters detail the four major muscle groups with composite illustrations of each region's deep and superficial muscles in both anterior and posterior views. Color tables show each muscle's origin, insertion, innervation, and action.

A final chapter by Thomas W. Myers outlines myofascial meridians, presenting a map of fascial tracks and illustrating how they wind longitudinally through series of muscles. This new approach to structural patterning has far-reaching implications for effective movement training and manual therapy treatment.

Three appendices illustrate cutaneous nerve supply and dermatomes (Appendix 1), the major skeletal muscles (Appendix 2), including detailed charts of the main muscles involved in movement, and the remaining body systems (Appendix 3).