Organizational Citizenship Behavior is believed to be able to increase organizational success in improving the quality of human resources, productivity and competitive advantage. This study aims to examine, analyze, and find the direct effect of Quality of Work Life and Career Development on Organizational Citizenship Behavior and the indirect effect of Quality of Work Life and Career Development on Organizational Citizenship Behavior through Organizational Commitment and Entrepreneurial Orientation. This research is an explanatory quantitative research through hypothesis testing to test the nature of the relationship and influence between variables. Statistical analysis used is the analysis of Structural Equation Modeling (SEM) AMOS both the measurement model and the structural model. Data were collected using a series of survey research instruments in the production department of 4 tire companies: PT, Multistrada Arah Sarana Tbk, PT. Gajah Tunggal Tbk, PT. Goodyear Indonesia Tbk and PT United Kingdom, totaling 11,728 with a total sample of 400 employees. The results showed that 1) Quality of Work Lifehad a positive and significant effect on Organizational Citizenship Behavior; 2) Career Development has a positive and significant effect on Organizational Citizenship Behavior; 3) Quality of Work Life has a positive and significant effect on Organizational Commitment; 4) Organizational Commitment has a positive and significant effect on Organizational Citizenship Behavior; 5) Career Development has a positive and significant effect on Entrepreneurial Orientation; 6) Entrepreneurial Orientation has a positive and significant effect on Organizational Citizenship Behavior; 7) Quality of Work Life has a positive indirect effect on Organizational Citizenship Behavior through Organizational Commitment and 8) Career Development has a positive indirect effect on Organizational Citizenship Behavior through Entrepreneurial Orientation.Keywords: Organizational Citizenship Behavior, Quality of Work Life, Career Development, Organizational Commitment, Entrepreneurial Orientation